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A small cluster of D1/D2 hybrid neurons showed distinct differences, suggesting a unique role in AUD

Human twin studies and animal research demonstrate that these genes significantly influence smoking behavior, nicotine dependence, and quit success by controlling how nicotine interacts with the brains reward system, particularly in the dopaminergic cells of the ventral tegmental area and nucleus accumbens These genetic factors make certain people more likely to develop tobacco dependence compared to others

PEER's Bennett similarly said that "you don't get to just ignore the stuff that doesn't support your hypothesis

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